初步推断死因的方法以及检测内源性代谢产物的方法

本发明属于法医学技术领域，尤其涉及一种基于内源性代谢产物初步推断死因的方法。该方法以血液样本中乙酰肉碱、丙酰肉碱、琥珀酸作为差异代谢产物，通过对其的定量分析结合数学建模来实现对未知血液样本的主体进行致死原因的初步推断，可用于初步判断死亡案例的致死因素是否为抗精神病药过量使用而中毒，涉及的抗精神病药包括氯丙嗪、奋乃静、奥氮平、氯氮平中的一种或多种。本发明还涉及一种检测内源性代谢产物的方法，用于检测血液样本中服用氯丙嗪、奋乃静、奥氮平、氯氮平后产生的内源性代谢产物。 The invention belongs to the technical field of forensic medicine, and particularly relates to a method for preliminarily deducing a dead cause based on endogenous metabolites. According to the method, acetylcarnitine, propionyl carnitine and succinic acid in a blood sample are taken as differential metabolites, preliminary deduction of lethal reasons of a main body of an unknown blood sample is realized by combining quantitative analysis with mathematical modeling, and the method can be used for preliminarily judging whether the lethal factors of a death case are poisoning caused by excessive use of antipsychotic drugs or not; and the related antipsychotic drug comprises one or more of chlorpromazine, perphenazine, olanzapine and clozapine. The invention further relates to a met