PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]PYRAZOLE-4-CARBOXAMIDE
The application relates to a process for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I). The process includes (i) synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a pyrazole ester intermediate which...
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| creator | DAHMEN THOMAS SONG LICHENG SCHEIPERS CLAUDIA CLEATOR EDWARD CHASSAING CHRISTOPHE PIERRE ALAIN XIAO WENSONG SCHMIDT HEIDEMARIE YIN JINGJUN SALANTA DANIEL |
| description | The application relates to a process for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I). The process includes (i) synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a pyrazole ester intermediate which can be obtained in enantiopure form and (iii) combination of these intermediates into compound (I).
本申请涉及一种制备1-[(3R,4S)-4-氰基四氢吡喃-3-基]-3-[(2-氟-6-甲氧基-4-吡啶基)氨基]吡唑-4-甲酰胺(I)的方法，其中包括(i)合成溴和碘吡啶中间体，(ii)合成可以以对映体纯形式获得的吡唑酯中间体和(iii)组合这些中间体形成化合物(I)。 |
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本申请涉及一种制备1-[(3R,4S)-4-氰基四氢吡喃-3-基]-3-[(2-氟-6-甲氧基-4-吡啶基)氨基]吡唑-4-甲酰胺(I)的方法，其中包括(i)合成溴和碘吡啶中间体，(ii)合成可以以对映体纯形式获得的吡唑酯中间体和(iii)组合这些中间体形成化合物(I)。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjMEKgkAURd20iOofbKfQg3Qk19M4pjDNk6eBk4hITKsowXb9fAp9QJt74XLOXTqfglDIsnRTJLcgWXDK9ckNoPEY7aLShwiE4RorWRHPTEJYGOIaGBjVTtl4IaTqgoRwgLOsMqzN5ExQnhjl83OusZ2VKyo5n3E6Yj3NiVw7i3v_GO3m1ytnm8pKZGCHV2fHob_Zp313QgcBC8N4H8ec_cN8ASEKOrE</recordid><startdate>20210806</startdate><enddate>20210806</enddate><creator>DAHMEN THOMAS</creator><creator>SONG LICHENG</creator><creator>SCHEIPERS CLAUDIA</creator><creator>CLEATOR EDWARD</creator><creator>CHASSAING CHRISTOPHE PIERRE ALAIN</creator><creator>XIAO WENSONG</creator><creator>SCHMIDT HEIDEMARIE</creator><creator>YIN JINGJUN</creator><creator>SALANTA DANIEL</creator><scope>EVB</scope></search><sort><creationdate>20210806</creationdate><title>PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]PYRAZOLE-4-CARBOXAMIDE</title><author>DAHMEN THOMAS ; SONG LICHENG ; SCHEIPERS CLAUDIA ; CLEATOR EDWARD ; CHASSAING CHRISTOPHE PIERRE ALAIN ; XIAO WENSONG ; SCHMIDT HEIDEMARIE ; YIN JINGJUN ; SALANTA DANIEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113227077A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>DAHMEN THOMAS</creatorcontrib><creatorcontrib>SONG LICHENG</creatorcontrib><creatorcontrib>SCHEIPERS CLAUDIA</creatorcontrib><creatorcontrib>CLEATOR EDWARD</creatorcontrib><creatorcontrib>CHASSAING CHRISTOPHE PIERRE ALAIN</creatorcontrib><creatorcontrib>XIAO WENSONG</creatorcontrib><creatorcontrib>SCHMIDT HEIDEMARIE</creatorcontrib><creatorcontrib>YIN JINGJUN</creatorcontrib><creatorcontrib>SALANTA DANIEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DAHMEN THOMAS</au><au>SONG LICHENG</au><au>SCHEIPERS CLAUDIA</au><au>CLEATOR EDWARD</au><au>CHASSAING CHRISTOPHE PIERRE ALAIN</au><au>XIAO WENSONG</au><au>SCHMIDT HEIDEMARIE</au><au>YIN JINGJUN</au><au>SALANTA DANIEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]PYRAZOLE-4-CARBOXAMIDE</title><date>2021-08-06</date><risdate>2021</risdate><abstract>The application relates to a process for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I). The process includes (i) synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a pyrazole ester intermediate which can be obtained in enantiopure form and (iii) combination of these intermediates into compound (I).
本申请涉及一种制备1-[(3R,4S)-4-氰基四氢吡喃-3-基]-3-[(2-氟-6-甲氧基-4-吡啶基)氨基]吡唑-4-甲酰胺(I)的方法，其中包括(i)合成溴和碘吡啶中间体，(ii)合成可以以对映体纯形式获得的吡唑酯中间体和(iii)组合这些中间体形成化合物(I)。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]PYRAZOLE-4-CARBOXAMIDE |
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