PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]PYRAZOLE-4-CARBOXAMIDE

PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]PYRAZOLE-4-CARBOXAMIDE

The application relates to a process for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I). The process includes (i) synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a pyrazole ester intermediate which...

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Hauptverfasser: DAHMEN THOMAS, SONG LICHENG, SCHEIPERS CLAUDIA, CLEATOR EDWARD, CHASSAING CHRISTOPHE PIERRE ALAIN, XIAO WENSONG, SCHMIDT HEIDEMARIE, YIN JINGJUN, SALANTA DANIEL
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The application relates to a process for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I). The process includes (i) synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a pyrazole ester intermediate which can be obtained in enantiopure form and (iii) combination of these intermediates into compound (I). 本申请涉及一种制备1-[(3R,4S)-4-氰基四氢吡喃-3-基]-3-[(2-氟-6-甲氧基-4-吡啶基)氨基]吡唑-4-甲酰胺(I)的方法，其中包括(i)合成溴和碘吡啶中间体，(ii)合成可以以对映体纯形式获得的吡唑酯中间体和(iii)组合这些中间体形成化合物(I)。