Modified nonapeptide, preparation method therefor and application of modified nonapeptide

The invention discloses a modified nonapeptide. The modified nonapeptide is an alkylation-and-acylation-modified and/or phosphorylation-modified nonapeptide. In which, an amino acid sequence of an alkylation-and-acylation-modified nonapeptide is a sequence I: R-CO-Trp-Ala-Gly-Gly-Phe-Ala-Ser-Gly-Glu...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN YI, LIU BING, DENG LIANWU, YANG CUIPING, GAO EN'EN, DONG JUNJUN, LI YUCHUAN, XUE KE, LYU XINGZHI, CHEN NENG'AN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses a modified nonapeptide. The modified nonapeptide is an alkylation-and-acylation-modified and/or phosphorylation-modified nonapeptide. In which, an amino acid sequence of an alkylation-and-acylation-modified nonapeptide is a sequence I: R-CO-Trp-Ala-Gly-Gly-Phe-Ala-Ser-Gly-Glu, wherein R is unbranched or branched paraffin containing 1-18 carbon atoms; an amino acid sequence of a phosphorylation-modified nonapeptide is a sequence II: Trp-Ala-Gly-Gly-Phe-Ala-Ser(PO3H)-Gly-Glu, wherein R is unbranched or branched paraffin containing 1-18 carbon atoms; and an amino acid sequence of a phosphorylation-modified or alkylation-and-acylation-modified nonapeptide is a sequence III: R-CO-Trp-Ala-Gly-Gly-Phe-Ala-Ser(PO3H)-Gly-Glu, wherein R is unbranched or branched paraffin containing 1-18 carbon atoms. Compared with sigma-sleep-inducing peptide (DSIP) with the highest sleep-inducing activity among known peptides, the modified nonapeptide disclosed by the invention has the advantages that the sleep