Polyethylene glycol-phenylboronic acid modified dendrimer-wrapping copper ion/Tirapazamine complex, preparation method therefor and application of polyethylene glycol-phenylboronic acid modified dendrimer-wrapping copper ion/Tirapazamine complex

The invention relates to a polyethylene glycol-phenylboronic acid modified dendrimer-wrapping copper ion/Tirapazamine complex, a preparation method therefor and application of the polyethylene glycol-phenylboronic acid modified dendrimer-wrapping copper ion/Tirapazamine complex. The method comprises the steps of preparing of PBA-PEG-COOH, preparing of G5-PEG-PBA, preparing of G5. NHAc-PEG-PBA, preparing of G5.NHAc-PEG-PBA@Cu(II) solution and preparing of G5. NHAc-PEG-PBA@Cu(II)/TPZ solution. The method is simple, is easy in operation, separation and purification and low in cost of raw materials employed and has a good prospect for development; and the prepared polyethylene glycol-phenylboronic acid modified dendrimer nano-platform has a specific targeted treatment function and an enhanced chemical drug and chemical kinetics combined treatment effect and has a good application prospect in the aspect of combined treatment. 本发明涉及一种聚乙二醇-苯硼酸修饰的树状大分子包裹铜离子/替拉扎明复合物及其制备方法和应用。该方法包括：PBA-PEG-COOH制备，G5-PEG-PBA制备，G5.NHAc-P