Method for refining favipiravir and/or derivatives thereof

The invention relates to a method for refining favipiravir and/or derivatives thereof, which comprises the following steps of dissolving favipiravir and/or derivatives thereof to be refined in an organic solvent A, filtering with silica gel, drying and purifying to obtain the favipiravir. The purifi...

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Bibliographische Detailangaben
Hauptverfasser: LI CHENGLIN, XU YANJUN, DENG SHENGJU, LIU HUIQIANG, LI QIANG, WANG TIANYUAN, ZENG ENYOU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a method for refining favipiravir and/or derivatives thereof, which comprises the following steps of dissolving favipiravir and/or derivatives thereof to be refined in an organic solvent A, filtering with silica gel, drying and purifying to obtain the favipiravir. The purification is selected from any one or a combination of recrystallization and pulping. According to the refining method, the problem that favipiravir is difficult to decolor is solved, and the obtained product is a white or off-white powdery product and meets related requirements of drug quality standards. In addition, the method is suitable for purification and decoloration of other products and intermediates, and is high in decoloration degree, good in purification effect, simple and convenient to operate, low in cost and suitable for industrial production. 本发明涉及一种法匹拉韦和/或其衍生物的精制方法,包括如下步骤:将待精制的法匹拉韦和/或其衍生物溶于有机溶剂A中,经硅胶过滤后,干燥,纯化,即得。所述纯化选自重结晶、打浆的任一种或其组合。该精制方法解决了法匹拉韦难以脱色的问题,所得产品为白色或类白色粉末状产品,符合药品质量标准的相关要求。另外,该方法适用于其他产品及中间体的