Application of pennoside compound

The invention belongs to the technical field of medicines, and particularly discloses application of a pennoside compound and pharmaceutically acceptable salt thereof in preparation of medicines for treating rheumatoid arthritis. In-vivo and in-vitro researches show that the pennoside compound PSVII acts on RA synovial cells to inhibit the proliferation of RA-FLS and MH7A and induce the apoptosis of the RA-FLS and MH7A. The compound can reduce the levels of serum TNF-alpha, IL-6 and IL-1beta, improve inflammatory cell infiltration, synovial hyperplasia and arthritis pathological changes of cartilage and bone erosion, relieve toe swelling, reduce the degree of ankle joint diameter swelling, and down-regulate the arthritis, thymus and spleen indexes The pennoside compound can be used for preparing medicines for treating rheumatoid arthritis. 本发明属于医药技术领域，具体公开一种偏诺皂苷类化合物及其药学上可接受的盐在制备治疗类风湿性关节炎药物中的应用。体内外研究表明，偏诺皂苷类化合物PSVII通过作用于RA滑膜细胞，抑制RA-FLS和MH7A的增殖、诱导其凋亡，能够降低血清TNF-α、IL-6及IL-1β水平，改善炎性细胞浸润、滑膜增生、软骨及骨侵蚀的关节炎病理变化，缓解足趾肿胀，