Application of ferroptosis inhibitor in preparation of preparation for improving motion function of aged individuals

The invention discloses an application of a ferroptosis inhibitor in preparation of a preparation for improving the motion function of aged individuals. Through transcriptome sequencing analysis, Tfr1 expression in skeletal muscle and muscle satellite cells is reduced along with age increase. The sp...

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Hauptverfasser: DING HONGRONG, XU GUOHUAN, HAN MULAN, XIE LIWEI, PAN GUIHUA, LIU ZHIHONG, LIU BINGDONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses an application of a ferroptosis inhibitor in preparation of a preparation for improving the motion function of aged individuals. Through transcriptome sequencing analysis, Tfr1 expression in skeletal muscle and muscle satellite cells is reduced along with age increase. The specific knockout of the Tfr1 muscle satellite cells leads to irreversible inactivation of the muscle satellite cells. The skeletal muscle regeneration process of the Tfr1 muscle satellite cell specific mouse is accompanied by amyotrophy, iron ion accumulation and increase of unsaturated fatty acid biosynthesis, and then skeletal muscle ferroptosis is induced. The senescent skeletal muscle shows that the expression of Tfr1 is reduced, and the surface of an Slc39a14 membrane is enriched, so that the absorption of non-iron transporter binding iron is promoted to be increased, and the occurrence of ferroptosis is promoted. By intraperitoneal injection of the Ferrostatin-1 into aged mice, muscle aplastic disorder and dys