Application of cobaltosic oxide as matrix in MALDI-TOF MS detection of small molecules

The invention discloses application of cobaltosic oxide as a matrix in MALDI-TOF MS detection of small molecules, and relates to the field of nano material synthesis and mass spectrometry detection. The nano cobaltosic oxide particles are simple and controllable in preparation method, regular in morphology, uniform in size, low in cost and good in water solubility, and can avoid the problem of matrix interference when a traditional organic matrix is used for detecting small molecule compounds when the nano cobaltosic oxide particles serve as an MALDI-TOFMS matrix. When the carbon-based material is used as a laser desorption ionization auxiliary matrix, the operability of mass spectrum detection is strong, the repeatability is good, and the high-flux and high-sensitivity analysis of the MALDI-TOFMS on small molecule compounds is realized. The invention also discloses the application of the cobaltosic oxide as a matrix in MALDI-TOF MS detection of small molecules. And high-sensitivity and high-throughput analys