Application of exosome circular RNA 0001359 in prevention and treatment of benign prostatic hyperplasia

The invention belongs to the field of biotechnology and benign prostatic hyperplasia, and particularly relates to application of exosome circular RNA 0001359 in prevention and treatment of benign prostatic hyperplasia, and the sequence of the exosome circular RNA 0001359 is shown as SEQ ID NO. 1. By...

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Hauptverfasser: LIU MIN, LIU JIANHUA, RONG NAN, CHEN JINGLOU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the field of biotechnology and benign prostatic hyperplasia, and particularly relates to application of exosome circular RNA 0001359 in prevention and treatment of benign prostatic hyperplasia, and the sequence of the exosome circular RNA 0001359 is shown as SEQ ID NO. 1. By inhibiting the hsa_circ_0001359, the proliferation of the RWPE-1 can be inhibited. Moreover, the benign prostatic hyperplasia marker exosome hsa_circ_0001359 has expression difference in peripheral blood of healthy people and benign prostatic hyperplasia patients, so that the benign prostatic hyperplasia marker exosome hsa_circ_0001359 can be used as a novel biomarker for detecting benign prostatic hyperplasia. The invention finds that the exosome hsa_circ_0001359 can be used as a biomarker and a drug treatment target for benign prostatic hyperplasia diagnosis for the first time, and provides a new reference index for developing a drug for preventing and treating benign prostatic hyperplasia. 本发明属于生物技术与良性前列腺增生领域,具