PROTEASE ENZYME VARIANTS AND USES THEREOF

The present invention is related to variants of fungal serine protease enzyme, which have serine protease activity of Malbranchea protease. Also disclosed are isolated nucleic acid molecules, comprising polynucleotide sequences which encode variants of fungal serine protease enzyme, nucleic acid sequences encoding said protease variants. Also disclosed are a host cell and a process of producing polypeptides having serine protease activity. Said protease variants are useful as enzyme preparations applicable in detergent compositions and for treating fibers, wool, hair, leather, or silk, for treating food or feed, or for any applications involving modification, degradation or removal of proteinaceous material. 本发明涉及真菌丝氨酸蛋白酶的变体，其具有畸枝霉属蛋白酶的丝氨酸蛋白酶活性。还公开了分离的核酸分子，其包含编码真菌丝氨酸蛋白酶变体多核苷酸序列、编码所述蛋白酶变体的核酸序列。还公开了宿主细胞和生产具有丝氨酸蛋白酶活性的多肽的方法。所述蛋白酶变体可用作适用于去污剂组合物和酶制剂，用于处理纤维、羊毛、毛发、皮革或丝绸、用于处理食品或饲料、或用于涉及蛋白质材料的修饰、降解或去除中的任何应用。