DEUTERATED DIHYDROPYRIMIDINE COMPOUND AND USE THEREOF AS DRUG

A deuterated dihydropyrimidine compound and use thereof as a drug, especially as a drug for treating and preventing hepatitis B. In particular, the present invention relates to a compound represented by general formula (I) or (Ia) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variate is as defined in the description. The present invention also relates to use of the compound represented by general formula (I) or (Ia) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, or a pharmaceutically acceptable salt thereof as a drug, in particular as a drug for treating and preventing hepatitis B. 本发明涉及一种氘代二氢嘧啶类化合物及其作为药物的用途，尤其是作为治疗和预防乙型肝炎的药物的应用。具体地说，本发明涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药，其中各变量如说明书所定义。本发明还涉及通式(I)或(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐作为药物的用途，尤其是作为治疗和预防乙型肝炎的药物的用途。