METHODS OF PRODUCING PYRAZOLE COMPOUNDS

The present invention is directed to methods of producing substituted pyrazole based compounds through novel intermediates and unique processes for preparing such intermediates which enables synthesis of final product through commercially viable route of synthesis. The present invention is also directed to novel methods of producing substituted pyrazole based thyroid like compounds, and solid forms of 3-{4-[(7-hydroxy-6-methyl-indan-4-yl)methyl]-3,5-dimethyl-1H-pyrazol-1-yl}-propanoic acid, its pharmaceutical compositions, and methods of preparation thereof. 本发明涉及通过新型中间体生产取代的吡唑基化合物的方法以及使得能够通过商业可行的合成路线合成最终产物的用于制备这类中间体的独特方法。本发明还涉及生产取代的吡唑基甲状腺样化合物的新型方法，和固体形式的3-{4-[(7-羟基-6-甲基-茚满-4-基)甲基]-3,5-二甲基-1H-吡唑-1-基}-丙酸、其药物组合物及其制备方法。