BI-FUNCTIONAL FUSION PROTEINS AND USES THEREOF

The present invention provides a bi-functional fusion protein simultaneously targeting the complement and the vascular endothelial growth factor (VEGF). The bi-functional fusion proteins contain two or more domains of human proteins and are of all human sequences, and thus are expected to be non-imm...

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Bibliographische Detailangaben
Hauptverfasser:	LIU JUNXIANG, WANG YUNTING, LI ZHENGGE, LIN LICEN, XU CHONGYUAN, CHEN HUANGCI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a bi-functional fusion protein simultaneously targeting the complement and the vascular endothelial growth factor (VEGF). The bi-functional fusion proteins contain two or more domains of human proteins and are of all human sequences, and thus are expected to be non-immunogenic, and potentially can be used therapeutically in human targeting complement and VEGF related diseases. 本发明提供了同时以补体及血管内皮生长因子(vascular endothelial growth factor,VEGF)为标靶的双功能性融合蛋白。该双功能性融合蛋白包含二个或多个的人类蛋白结构域，且为所有人类序列的，因此预期是非免疫原性的，并潜在地可用于治疗人体中与以补体及血管内皮生长因子(VEGF)为标靶的相关疾病。