COMBINATORIAL CANCER IMMUNOTHERAPY

Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well a...

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Hauptverfasser:	GARRISON BRIAN SCOTT, GONZALEZ-JUNCA ALBA, FRIMANNSSON DANIEL, LIN JACK TZUIAO, LEE PHILIP JANMIN, WANG DON-HONG, GORDLEY RUSSELL MORRISON, LU TIMOTHY KUAN-TA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer. 本文提供了用于动态控制和靶向癌症的多种免疫抑制机制的方法和组合物。一些方面提供了被工程化用于产生多种各自调节肿瘤的不同免疫抑制机制的效应分子的细胞，以及使用所述细胞治疗例如卵巢癌、乳腺癌或结肠癌的癌症的方法。