Method for improving pig health by targeted inactivation of CD163

The present invention relates to methods and compositions for preventing porcine reproductive and respiratory syndrome (PRRSv) in animals, including animals of a population of pigs. The present teachings relate to pigs in which at least one allele of the CD163 gene has been inactivated, and specific...

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Bibliographische Detailangaben
Hauptverfasser:	BERG BRIAN, ANDREW MARK CHIGAN, JONATHAN EDWARD LIGHTNER, MATTHEW CAMPBELL, DYLAN BARNES, BENJAMIN BEATON, MATTHEW SCOTT CULBERTSON, WILLIAM THOMAS CHRISTIANSEN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to methods and compositions for preventing porcine reproductive and respiratory syndrome (PRRSv) in animals, including animals of a population of pigs. The present teachings relate to pigs in which at least one allele of the CD163 gene has been inactivated, and specific methods and nucleic acid sequences for inactivating the CD163 gene in gene editing. The pig of which the two alleles of the CD163 gene are inactivated has resistance to porcine reproductive and respiratory syndrome (PRRSv). The superior lines comprising the homozygous CD163 editing gene retain their superior characteristics. 本发明涉及用于在动物（包括猪种群的动物）中预防猪繁殖和呼吸障碍综合症（PRRSv）的方法和组合物。本发明教导涉及其中CD163基因的至少一个等位基因已失活的猪，以及用于在基因编辑中失活CD163基因的具体方法和核酸序列。CD163基因的两个等位基因均失活的猪，对猪繁殖和呼吸障碍综合症（PRRSv）具有抵抗力。包含纯合CD163编辑基因的优良系保留了它们的优异特性。