Preparation method of 2-amino-2-(1-methyl-4-piperidyl)ethanol
The invention discloses a preparation method of 2-amino-2-(1-methyl-4-piperidyl) ethanol. The preparation method comprises the following steps: reacting 2-methyl-2-propyl-4-(1-amino-2-methoxy-2-oxoethyl)-1-piperidinecarboxylate (a compound II) with benzyl bromide under the action of an alkali 1 to g...
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| creator | LIU WENBO YU SHANBAO ZHU CHUNRUI |
| description | The invention discloses a preparation method of 2-amino-2-(1-methyl-4-piperidyl) ethanol. The preparation method comprises the following steps: reacting 2-methyl-2-propyl-4-(1-amino-2-methoxy-2-oxoethyl)-1-piperidinecarboxylate (a compound II) with benzyl bromide under the action of an alkali 1 to generate a compound III; dissolving the compound III in an organic solvent, and generating a compound IV under the action of a reducing agent; and removing benzyl from the compound IV under the action of a catalyst/hydrogen to generate a compound I.
本发明公开了一种2-氨基-2-(1-甲基-4-哌啶基)乙醇的制备方法，包括以下步骤：将2-甲基-2-丙烷基-4-(1-氨基-2-甲氧基-2-氧代乙基)-1-哌啶羧酸酯(化合物II)在碱1作用下与溴化苄反应生成化合物III；化合物III溶于有机溶剂中，在还原剂作用下生成化合物IV；化合物IV在催化剂/氢气作用下，脱除苄基生成化合物I。 |
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本发明公开了一种2-氨基-2-(1-甲基-4-哌啶基)乙醇的制备方法，包括以下步骤：将2-甲基-2-丙烷基-4-(1-氨基-2-甲氧基-2-氧代乙基)-1-哌啶羧酸酯(化合物II)在碱1作用下与溴化苄反应生成化合物III；化合物III溶于有机溶剂中，在还原剂作用下生成化合物IV；化合物IV在催化剂/氢气作用下，脱除苄基生成化合物I。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210723&DB=EPODOC&CC=CN&NR=113149891A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210723&DB=EPODOC&CC=CN&NR=113149891A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU WENBO</creatorcontrib><creatorcontrib>YU SHANBAO</creatorcontrib><creatorcontrib>ZHU CHUNRUI</creatorcontrib><title>Preparation method of 2-amino-2-(1-methyl-4-piperidyl)ethanol</title><description>The invention discloses a preparation method of 2-amino-2-(1-methyl-4-piperidyl) ethanol. The preparation method comprises the following steps: reacting 2-methyl-2-propyl-4-(1-amino-2-methoxy-2-oxoethyl)-1-piperidinecarboxylate (a compound II) with benzyl bromide under the action of an alkali 1 to generate a compound III; dissolving the compound III in an organic solvent, and generating a compound IV under the action of a reducing agent; and removing benzyl from the compound IV under the action of a catalyst/hydrogen to generate a compound I.
本发明公开了一种2-氨基-2-(1-甲基-4-哌啶基)乙醇的制备方法，包括以下步骤：将2-甲基-2-丙烷基-4-(1-氨基-2-甲氧基-2-氧代乙基)-1-哌啶羧酸酯(化合物II)在碱1作用下与溴化苄反应生成化合物III；化合物III溶于有机溶剂中，在还原剂作用下生成化合物IV；化合物IV在催化剂/氢气作用下，脱除苄基生成化合物I。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLANKEotSCxKLMnMz1PITS3JyE9RyE9TMNJNzM3My9c10tUw1AUJV-bomugWZBakFmWmVOZoAkUS8_JzeBhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvLOfoaGxoYmlhaWhozExagCKnC71</recordid><startdate>20210723</startdate><enddate>20210723</enddate><creator>LIU WENBO</creator><creator>YU SHANBAO</creator><creator>ZHU CHUNRUI</creator><scope>EVB</scope></search><sort><creationdate>20210723</creationdate><title>Preparation method of 2-amino-2-(1-methyl-4-piperidyl)ethanol</title><author>LIU WENBO ; YU SHANBAO ; ZHU CHUNRUI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113149891A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU WENBO</creatorcontrib><creatorcontrib>YU SHANBAO</creatorcontrib><creatorcontrib>ZHU CHUNRUI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU WENBO</au><au>YU SHANBAO</au><au>ZHU CHUNRUI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of 2-amino-2-(1-methyl-4-piperidyl)ethanol</title><date>2021-07-23</date><risdate>2021</risdate><abstract>The invention discloses a preparation method of 2-amino-2-(1-methyl-4-piperidyl) ethanol. The preparation method comprises the following steps: reacting 2-methyl-2-propyl-4-(1-amino-2-methoxy-2-oxoethyl)-1-piperidinecarboxylate (a compound II) with benzyl bromide under the action of an alkali 1 to generate a compound III; dissolving the compound III in an organic solvent, and generating a compound IV under the action of a reducing agent; and removing benzyl from the compound IV under the action of a catalyst/hydrogen to generate a compound I.
本发明公开了一种2-氨基-2-(1-甲基-4-哌啶基)乙醇的制备方法，包括以下步骤：将2-甲基-2-丙烷基-4-(1-氨基-2-甲氧基-2-氧代乙基)-1-哌啶羧酸酯(化合物II)在碱1作用下与溴化苄反应生成化合物III；化合物III溶于有机溶剂中，在还原剂作用下生成化合物IV；化合物IV在催化剂/氢气作用下，脱除苄基生成化合物I。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Preparation method of 2-amino-2-(1-methyl-4-piperidyl)ethanol |
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