Method for establishing pulmonary edema rabbit animal model

The invention discloses a method for establishing a pulmonary edema rabbit animal model, belongs to the field of biological model construction, and aims to overcome the defect that in the prior art, complicating respiratory system symptoms are generated by reducing heart rate or other external circu...

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Bibliographische Detailangaben
Hauptverfasser: GUO GUO, LIU JING, ZONG HAIFENG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a method for establishing a pulmonary edema rabbit animal model, belongs to the field of biological model construction, and aims to overcome the defect that in the prior art, complicating respiratory system symptoms are generated by reducing heart rate or other external circulation influences. In order to overcome the defects, according to the technical scheme, a medicament for changing the increase of the lung water content is externally and discontinuously injected into an animal to be experimented, so that the liquid content in pulmonary interstitial substances, pulmonary alveoli and cells is increased, and the model is induced to generate pulmonary edema lesion. Compared with the prior art of an oleic acid injection method, an epinephrine instillation method and a chloroform injection method, in the technical scheme, the medicament is directly perfused into the lung to change the concentration of lung water, so that mutagenesis is realized, the influence of heart rate or other exte