Cefixime impurity and preparation method thereof

The invention discloses a cefixime impurity and a preparation method thereof, and belongs to the field of medicine synthesis. According to the method, cefixime serves as a starting raw material, CefiximeSulfone is obtained through acid catalysis esterification, oxidation and hydrolysis, the route design is reasonable, the raw materials are easy to obtain, operability is high, purification is convenient, aftertreatment is simple, the purity of the prepared target product can reach 99.5% or above, a reference sample is provided for cefixime research, a reference substance for analysis and research can be provided for clinical, pharmacological and pharmacokinetics of cefixime, and the method has important research value in clinical pharmacokinetics research. 本发明公开了一种头孢克肟杂质及其制备方法，属于药物合成领域。本申请方法以头孢克肟为起始原料，通过酸催化酯化、氧化、再经过水解得到CefiximeSulfone，路线设计合理、原料易得，可操作性强、提纯方便，后处理简单，制备得到的目标产物纯度可达99.5％以上，为头孢克肟研究提供参照样品，能为头孢克肟的临床、药理、药代动力学提供分析研究的基准物质，在临床药代动力学研究中具有重要研究价值。