Avian infectious bronchitis cell-adapted virus and application thereof

The invention discloses an avian infectious bronchitis cell-adapted virus and application thereof, and belongs to the field of vaccine production. The avian infectious bronchitis cell-adapted virus is obtained by alternately passing and domesticating the avian infectious bronchitis virus (IBV) in a chick embryo and an AGE1 cell, the cell-adapted virus can stably grow and pass in the AGE1 cell, the immunogenicity is kept, and animals can effectively generate immunity against the IBV. The cell-adapted virus is of great significance to the capacity upgrading of IBV vaccines. 本发明公开了一株鸡传染性支气管炎细胞适应毒及其应用，属于疫苗生产领域。本发明的鸡传染性支气管炎细胞适应毒是将鸡传染性支气管炎病毒(IBV)在鸡胚和AGE1细胞交替传代，驯化得到，该细胞适应毒可在AGE1细胞中稳定生长和传代，且保持免疫原性，使动物有效产生针对IBV的免疫力。本发明的细胞适应毒对IBV疫苗产能升级具有十分重大的意义。