Beta-amino acid derivative, kinase inhibitor containing beta-amino acid derivative, pharmaceutical composition and application thereof

A compound represented by Formula (I), a pharmaceutically acceptable salt or ester, hydrate, solvate or crystalline form thereof is provided. The compound represented by Formula (I) is a beta-amino acid derivative, and in Formula (I): X is a single bond or O; Y is NH or C=O; Z is C=O, C=S, NH,W is C or N; A is a single bond, O, OH, OCH2, a heterocycle or N3; R1 is H or F; R2 is H, F, OH, CF3, CH2OH, CHO or; R3 is H; n is 0 or 1; and m is 0 or 1. 提供一种式(I)所示之化合物或其药学上可接受之盐或酯、水合物、溶剂合物或结晶物，该式(I)所示之化合物为一β氨基酸衍生物，又于该式(I)中：X为单键或O；Y为NH或C＝O；Z为C＝O、C＝S、NH、或W为C或N；A为单键、O、OH、OCH2、杂环或N3；R1为H或F；R2为H、F、OH、CF3、CH2OH、CHO或R3为H；n为0或1；且m为0或1。