Novel piperidine derivative and pharmaceutical use thereof

The present disclosure relates to a novel piperidine derivative and pharmaceutical use thereof. Specifically, provided is a compound represented by formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer, a rotamer, a tautomer or a deuterated substance thereof. The compound has PDE4B1 or PDE4D3 inhibitory activity, and can be used for treating or preventing PDE4-related diseases, such as inflammatory diseases, diabetes or allergic diseases, and the definition of each group in the formula I is consistent with that in the description. 本公开涉及一种新型哌啶衍生物及其药物用途。具体而言，提供式I所示化合物或其可药用盐或其立体异构体、旋转异构体或互变异构体或氘代物，该类化合物具有PDE4B1或PDE4D3抑制活性，可用于治疗或预防与PDE4相关疾病，如炎症性疾病、糖尿病或变应性疾病，式I各基团定义与说明中一致。