Method for preparation of gadobenate dimeglumine complex in solid form

The present invention discloses a method for the preparation of gadobenate dimeglumine complex in a solid form. In particular, the solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions. 本发明公开了一种用于制备固体形式的钆贝葡胺络合物的方法。具体地，所述固体形式通过喷雾干燥在给定温度和浓度的对应液体悬浮液方便地得到。本发明对于工业规模而言是特别有利的，因为固体形式可以通过使用水作为溶剂来得到，所述水是无毒的溶剂，容易操作，并且基本上不需要麻烦健康或安全性预防措施。