Hydrogel scaffold with polydopamine coating and preparation method thereof

The invention relates to a preparation method of a hydrogel scaffold with a polydopamine coating, the preparation method comprises the following steps: dissolving anhydrous calcium chloride and a photoinitiator in deionized water, then adding modified gelatin and sodium alginate, and ultrasonically...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	QI HAISHENG, CHEN WENXIANG, FANG LIMING, SU JIANYU, PAN XIMAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ADDITIVE MANUFACTURING TECHNOLOGY ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PERFORMING OPERATIONS PROSTHESES TRANSPORTING TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	The invention relates to a preparation method of a hydrogel scaffold with a polydopamine coating, the preparation method comprises the following steps: dissolving anhydrous calcium chloride and a photoinitiator in deionized water, then adding modified gelatin and sodium alginate, and ultrasonically mixing uniformly to obtain mixed slurry; performing three-dimensional printing on the mixed slurry to obtain a pre-crosslinked composite scaffold; crosslinking the pre-crosslinked composite scaffold under ultraviolet light, and then soaking the pre-crosslinked composite scaffold in an anhydrous calcium chloride solution for secondary crosslinking to obtain a crosslinked composite scaffold; placing the cross-linked composite scaffold into a dopamine solution, taking out the cross-linked composite scaffold after reaction, washing the cross-linked composite scaffold with deionized water, and performing ultrasonic treatment to obtain the modified gelatin/sodium alginate composite scaffold with the polydopamine coating.