Preparation method of drug-loaded nanofiber nerve conduit

The invention discloses a preparation method of a drug-loaded nanofiber nerve conduit, the preparation method comprises the following steps: (1) taking chitosan and astragalus polysaccharide as raw materials, taking sodium tripolyphosphate as a cross-linking agent, and preparing astragalus polysaccharide nanospheres by using a chemical cross-linking method; (2) mixing the astragalus polysaccharide nanospheres with a gelatin solution, and then performing vacuum freeze drying to obtain a nerve conduit inner core; (3) dissolving gelatin and polylactic acid in hexafluoroisopropanol to prepare a spinning solution, and preparing a fibrous nerve conduit shell by using an electrostatic spinning method; and (4) filling the nerve conduit inner core into the cavity of the fibrous nerve conduit shell, then adding the nerve conduit inner core into a genipin solution for crosslinking, washing and then freeze-drying to obtain the nerve conduit. The nerve conduit prepared by the method has excellent biocompatibility, mechani