Chondroitin sulfate ES2 peptide and paclitaxel combined conjugate as well as preparation method and application thereof

The invention provides a chondroitin sulfate ES2 peptide conjugate as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The chondroitin sulfate-cystamine-ES2 peptide conjugates and/or paclitaxel-chondroitin sulfate-cystamine-ES2 peptide conjugates with different binding degrees are prepared by controlling the conditions of the supply quantity of CYS, ES2 peptide and PTX, the pH value of a reaction system, the reaction time and the like. Compared with an ES2 peptide, the chondroitin sulfate ES2 peptide combined cystamine and paclitaxel conjugate retains the anti-angiogenesis and anti-tumor activity of the ES2 peptide, and integrates the anti-tumor effect of PTX, so that the synthesized conjugate has higher stability, targeting property and biological activity, thereby having better use effect and application value. 本发明提供一种硫酸软骨素化ES2肽结合物及其制备方法和应用，属于生物医药技术领域。本发明通过控制CYS、ES2肽和PTX的供给量，反应体系的pH，反应时间等条件，制备得到具有不同结合度的硫酸软骨素～胱胺-ES2肽结合物和/或紫杉醇-硫酸软骨素～胱胺-ES2肽结合物。本