Nano preparation for targeted cardiac repair and preparation method thereof

The invention relates the field of biomedical engineering materials, in particular to a nano preparation for targeted cardiac repair and a preparation method thereof. The nano preparation is prepared from the following raw materials in parts by weight: 0.1-0.5 part of pterostilbene, 0.5-2 parts of arginine modified to copherylpolyethylene glycol 1000 succinate (TPGS-Arg), 1-3 parts of coenzyme Q10, 1-3 parts of soybean lecithin, 60-80 parts of glycerol, and 20-30 parts of deionized water. The nano preparation is a novel nano carrier material (coenzyme Q10-NEs-TPGS-Arg) developed by taking the pterostilbene as a drug model, and can repair myocardium in a targeted way. Thus, the purpose of increasing drug concentration at a lesion location is achieved. 本申请涉及生物医学工程材料领域，具体涉及一种用于心肌靶向修复的纳米制剂及其制备方法。所述纳米制剂由如下重量份的原料组分制成：紫檀芪0.1-0.5份、精氨酸修饰的聚乙二醇1000维生素E琥珀酸酯(TPGS-Arg)0.5-2份、辅酶Q10 1-3份，大豆卯磷脂1-3份，甘油60-80份，去离子水20-30份。利用紫檀芪为药物模型，开发出了一种新型的纳米载体材料(辅酶Q10-NEs-TPGS-Arg)，对心肌进行靶向性修复，实现了提高病灶部位的药物浓度的目的。