IMPROVED SYNTHETIC METHODS OF MAKING FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS

Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone are described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia and depression. 描述了用于制备(((3aR,6aS)-5-(4,6-二甲基嘧啶-2-基)六氢吡咯并[3,4-c]吡咯-2(1H)-基)(2-氟-6-(2H-1,2,3-三唑-2-基)苯基)甲酮的方法，所述方法可用于商业制造。所述化合物为食欲素受体调节剂，并且可用于治疗由食欲素活性介导的疾病状态、障碍和病症诸如失眠和抑郁症的药物组合物和方法中。