4-perfluoroalkyl substituted pyrimidine compound as well as preparation method and application thereof

The invention discloses a 4-perfluoroalkyl substituted pyrimidine compound as well as a preparation method and an application thereof. The method comprises the following steps: adding an alkali additive and a solvent into a reaction raw material formed by mixing a perfluoroalkyl substituted alkyne compound and amidine hydrochloride, stirring and reacting for 1-24 hours under the conditions of air atmosphere and 70 DEG C, determining a reaction process through TLC detection, obtaining a reaction product after the reaction is finished, washing, extracting and drying the reaction product, and carrying out column chromatography separation to obtain the 4-perfluoroalkyl substituted pyrimidine compound. The preparation method is mild in reaction condition, does not need an expensive transition metal catalyst, only uses inorganic base cesium carbonate as an additive, and has the characteristics of simple post-treatment, green steps, low pollution, high economic benefit and the like, and the prepared compound is a no