Pharmaceutical composition for treating rheumatoid arthritis
The invention relates to a pharmaceutical composition for treating rheumatoid arthritis. The pharmaceutical composition provided by the invention comprises tofacitinib or a salt thereof, and sinomenine or a salt thereof. It is found for the first time that tofacitinib and sinomenine are combined to...
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| creator | HU WEILIN DAI YANPING ZHANG JUNHUA HE MIN'ER FANG SILIANG GE TING ZOU HONGPING |
| description | The invention relates to a pharmaceutical composition for treating rheumatoid arthritis. The pharmaceutical composition provided by the invention comprises tofacitinib or a salt thereof, and sinomenine or a salt thereof. It is found for the first time that tofacitinib and sinomenine are combined to treat rheumatoid arthritis, have a very good synergistic effect, can significantly improve abnormal activity of TNF-alpha caused by rheumatoid arthritis and effectively reduce the content of TNF-alpha, so that inflammatory response is blocked, the joint function is improved, the process of rheumatoid arthritis is delayed, and the destructive effect of rheumatoid arthritis is relieved.
本发明涉及一种治疗类风湿性关节炎的药物组合物。本发明的药物组合物包括托法替布或其盐，以及包括青藤碱或其盐。本发明首次发现将托法替布联合青藤碱治疗类风湿性关节炎，相互具有很好的协同作用，可显著改善类风湿关节炎所致的TNF-α的异常活跃，有效降低TNF-α的含量，从而阻断炎症反应，改善关节功能，延缓类风湿性关节炎的进程，减轻类风湿性关节炎的破坏作用。 |
| format | Patent |
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本发明涉及一种治疗类风湿性关节炎的药物组合物。本发明的药物组合物包括托法替布或其盐，以及包括青藤碱或其盐。本发明首次发现将托法替布联合青藤碱治疗类风湿性关节炎，相互具有很好的协同作用，可显著改善类风湿关节炎所致的TNF-α的异常活跃，有效降低TNF-α的含量，从而阻断炎症反应，改善关节功能，延缓类风湿性关节炎的进程，减轻类风湿性关节炎的破坏作用。</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210622&DB=EPODOC&CC=CN&NR=112999226A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210622&DB=EPODOC&CC=CN&NR=112999226A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HU WEILIN</creatorcontrib><creatorcontrib>DAI YANPING</creatorcontrib><creatorcontrib>ZHANG JUNHUA</creatorcontrib><creatorcontrib>HE MIN'ER</creatorcontrib><creatorcontrib>FANG SILIANG</creatorcontrib><creatorcontrib>GE TING</creatorcontrib><creatorcontrib>ZOU HONGPING</creatorcontrib><title>Pharmaceutical composition for treating rheumatoid arthritis</title><description>The invention relates to a pharmaceutical composition for treating rheumatoid arthritis. The pharmaceutical composition provided by the invention comprises tofacitinib or a salt thereof, and sinomenine or a salt thereof. It is found for the first time that tofacitinib and sinomenine are combined to treat rheumatoid arthritis, have a very good synergistic effect, can significantly improve abnormal activity of TNF-alpha caused by rheumatoid arthritis and effectively reduce the content of TNF-alpha, so that inflammatory response is blocked, the joint function is improved, the process of rheumatoid arthritis is delayed, and the destructive effect of rheumatoid arthritis is relieved.
本发明涉及一种治疗类风湿性关节炎的药物组合物。本发明的药物组合物包括托法替布或其盐，以及包括青藤碱或其盐。本发明首次发现将托法替布联合青藤碱治疗类风湿性关节炎，相互具有很好的协同作用，可显著改善类风湿关节炎所致的TNF-α的异常活跃，有效降低TNF-α的含量，从而阻断炎症反应，改善关节功能，延缓类风湿性关节炎的进程，减轻类风湿性关节炎的破坏作用。</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAJyEgsyk1MTi0tyUxOzFFIzs8tyC_OLMnMz1NIyy9SKClKTSzJzEtXKMpILc1NLMnPTFFILCrJKAIqKeZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBUBj81JL4p39DA2NLC0tjYzMHI2JUQMAXZUw3Q</recordid><startdate>20210622</startdate><enddate>20210622</enddate><creator>HU WEILIN</creator><creator>DAI YANPING</creator><creator>ZHANG JUNHUA</creator><creator>HE MIN'ER</creator><creator>FANG SILIANG</creator><creator>GE TING</creator><creator>ZOU HONGPING</creator><scope>EVB</scope></search><sort><creationdate>20210622</creationdate><title>Pharmaceutical composition for treating rheumatoid arthritis</title><author>HU WEILIN ; DAI YANPING ; ZHANG JUNHUA ; HE MIN'ER ; FANG SILIANG ; GE TING ; ZOU HONGPING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN112999226A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HU WEILIN</creatorcontrib><creatorcontrib>DAI YANPING</creatorcontrib><creatorcontrib>ZHANG JUNHUA</creatorcontrib><creatorcontrib>HE MIN'ER</creatorcontrib><creatorcontrib>FANG SILIANG</creatorcontrib><creatorcontrib>GE TING</creatorcontrib><creatorcontrib>ZOU HONGPING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HU WEILIN</au><au>DAI YANPING</au><au>ZHANG JUNHUA</au><au>HE MIN'ER</au><au>FANG SILIANG</au><au>GE TING</au><au>ZOU HONGPING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pharmaceutical composition for treating rheumatoid arthritis</title><date>2021-06-22</date><risdate>2021</risdate><abstract>The invention relates to a pharmaceutical composition for treating rheumatoid arthritis. The pharmaceutical composition provided by the invention comprises tofacitinib or a salt thereof, and sinomenine or a salt thereof. It is found for the first time that tofacitinib and sinomenine are combined to treat rheumatoid arthritis, have a very good synergistic effect, can significantly improve abnormal activity of TNF-alpha caused by rheumatoid arthritis and effectively reduce the content of TNF-alpha, so that inflammatory response is blocked, the joint function is improved, the process of rheumatoid arthritis is delayed, and the destructive effect of rheumatoid arthritis is relieved.
本发明涉及一种治疗类风湿性关节炎的药物组合物。本发明的药物组合物包括托法替布或其盐，以及包括青藤碱或其盐。本发明首次发现将托法替布联合青藤碱治疗类风湿性关节炎，相互具有很好的协同作用，可显著改善类风湿关节炎所致的TNF-α的异常活跃，有效降低TNF-α的含量，从而阻断炎症反应，改善关节功能，延缓类风湿性关节炎的进程，减轻类风湿性关节炎的破坏作用。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Pharmaceutical composition for treating rheumatoid arthritis |
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