Pharmaceutical composition for treating rheumatoid arthritis

The invention relates to a pharmaceutical composition for treating rheumatoid arthritis. The pharmaceutical composition provided by the invention comprises tofacitinib or a salt thereof, and sinomenine or a salt thereof. It is found for the first time that tofacitinib and sinomenine are combined to treat rheumatoid arthritis, have a very good synergistic effect, can significantly improve abnormal activity of TNF-alpha caused by rheumatoid arthritis and effectively reduce the content of TNF-alpha, so that inflammatory response is blocked, the joint function is improved, the process of rheumatoid arthritis is delayed, and the destructive effect of rheumatoid arthritis is relieved. 本发明涉及一种治疗类风湿性关节炎的药物组合物。本发明的药物组合物包括托法替布或其盐，以及包括青藤碱或其盐。本发明首次发现将托法替布联合青藤碱治疗类风湿性关节炎，相互具有很好的协同作用，可显著改善类风湿关节炎所致的TNF-α的异常活跃，有效降低TNF-α的含量，从而阻断炎症反应，改善关节功能，延缓类风湿性关节炎的进程，减轻类风湿性关节炎的破坏作用。