Polysaccharide compound for long-acting inhibition of tumor postoperative recurrence and preparation and application thereof

The invention belongs to the technical field of postoperative treatment and biomedical engineering, and discloses a polysaccharide compound for long-acting inhibition of postoperative tumor recurrence and preparation and application thereof. The polysaccharide compound is formed by compounding raw m...

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Hauptverfasser: GU SAISAI, LIU XIQIU, WANG KAIPING, TENG-WANG TIANZI, NIE GANG, XU JINGYA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of postoperative treatment and biomedical engineering, and discloses a polysaccharide compound for long-acting inhibition of postoperative tumor recurrence and preparation and application thereof. The polysaccharide compound is formed by compounding raw materials including chitosan (CS) and lentinan (LNT). According to the compound, the dosage form of a lentinan tumor inhibitor is innovated and modified, so that the polysaccharide compound disclosed by the invention has good biocompatibility and can be slowly released locally for a long time, and compared with conventional adjuvant therapy-chemotherapy and radiotherapy for inhibiting postoperative tumor recurrence, the toxic and side effects of treatment are greatly reduced, and the long-time inhibition effect is improved. 本发明属于术后治疗、生物医学工程技术领域,公开了一种用于长效抑制肿瘤术后复发的多糖复合物及其制备与应用,该多糖复合物是由包括壳聚糖(CS)和香菇多糖(LNT)在内的原料复合而成。本发明是对香菇多糖肿瘤抑制剂的剂型进行创新改造,使得本发明中的多糖复合物具有良好的生物相容性的同时,能在局部保持长时间的缓慢释放,与常规的术后抑制肿瘤复发辅助治疗-化疗和放疗相比,大大降低了治疗的毒副作用,并提升