Pharmaceutical composition as well as preparation method and application thereof

The invention relates to a pharmaceutical composition as well as a preparation method and application thereof. The pharmaceutical composition is prepared from the following raw materials in percentage by mass: 5%-30% of doxycycline monohydrate, 1%-20% of a matrix carrier; and 50%-80% of a viscosity modifier; the matrix carrier is selected from at least one of caprylic acid/capric acid polyethylene glycol glyceride, propylene glycol dicaprylate/dicapric acid ester, starch, liquid paraffin, peanut oil and sesame oil; and the viscosity modifier is selected from at least one of microcrystalline wax, polyethylene wax, oxidized polyethylene wax, polypropylene wax, polyethylene glycol compounds, medium-chain triglyceride and glyceryl monolinoleate. The pharmaceutical composition can remarkably improve the bioavailability of doxycycline on cats and dogs, takes effect quickly after being orally taken by dogs and cats, and can quickly resist bacteria and diminish inflammation. In addition, the pharmaceutical compositio