Application of prismatomeris tetrandra monomer in liver protection
The invention discloses application of a prismatomeria tetrandra monomer in liver protection. The inventor performs high-throughput screening on prismatomeris tetrandra monomeric compounds (HG2, HG3 and HG4) extracted and separated from the ethyl acetate part of prismatomeris tetrandra, the result s...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses application of a prismatomeria tetrandra monomer in liver protection. The inventor performs high-throughput screening on prismatomeris tetrandra monomeric compounds (HG2, HG3 and HG4) extracted and separated from the ethyl acetate part of prismatomeris tetrandra, the result shows that the number of difference up-regulation genes is 21, and compared with a control group, the Klf15 expression difference has very significant difference. Due to the fact that Klf15 can regulate endogenous and exogenous metabolism of the liver, regulate expression of MMp3 and reduce the liver cell apoptosis level, it can be predicted that a prismatomeria tetrandra monomer can regulate the endogenous and exogenous metabolism of the liver by up-regulating expression of the Klf15 gene, and finally the liver protection effect is achieved. In conclusion, the prismatomeris tetrandra has incalculable potential in research and development of the liver protection medicine, and is worthy of further research and develo |
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