Application of composition in preparation of medicine for treating Alzheimer's disease

The invention discloses an application of a composition in preparation of a medicine for treating Alzheimer's disease. The composition contains pelargonisin and L-serine. The composition disclosed by the invention can generate an inhibiting effect on nerve cell injury caused by glutamate and reduce cell apoptosis. In addition, the composition can also reduce hyperphosphorylation of Tau in cells caused by okadaic acid molding. Meanwhile, the composition can significantly improve the learning and memory ability and learning and memory behaviors of animals in space and direction, alleviates inflammatory response of a brain, and has an excellent treatment effect on Alzheimer's disease and other neurodegenerative diseases. 本发明公开了一种组合物在制备阿尔兹海默症治疗药物中的应用，其中，该组合物中含有天竺葵素和L-丝氨酸。本发明中的组合物能够对谷氨酸盐造成的神经细胞损伤产生抑制作用，降低细胞凋亡。而且，该组合物还能降低因冈田酸造模引起的细胞内Tau的过度磷酸化。同时，该组合物能显著改善动物对空间和方向的学习记忆能力以及学习记忆行为，减轻大脑的炎症反应，对阿尔兹海默症等神经退行性疾病具有极佳的治疗效果。