Compositions and methods for treating CNS disorders

Disclosed herein are neuroactive steroids of Formula (I), or a pharmaceutically acceptable salt thereof, wherein (II), A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. In particular embodiments, these compounds are intended as GABA modulators. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of use and treatment, e.g., for inducing sedation and/or anesthesia. 本文公开了式(I)的神经活性类固醇，或其药学上可接受的盐；其中(II)、A、R1、R2、R3a、R4a、R4b、R5、R7a和R7b如本文所定义。在具体实施方案中，这些化合物预期作为GABA调节剂。本发明还提供了包含本发明化合物的药物组合物以及使用和治疗方法，例如，用于诱导镇静和/或麻醉。