METHODS AND SYSTEMS FOR ASSESSING MICROSATELLITE INSTABILITY

The invention disclosed herein generally relates to methods of assessing microsatellite instability in a subject. In an aspect, the present disclosure provides a computer-implemented method of assessing microsatellite instability of a subject, comprising: obtaining a quantitative measure of a plurality of microsatellite repeat elements from a blood sample of a subject; processing the plurality of quantitative measures to obtain a statistical measure of deviation of the plurality of quantitative measures; and detecting a presence of the microsatellite instability (MSI) of the subject when the statistical measure of deviation of the plurality of quantitative measures satisfies a predetermined criterion, or detecting an absence of the microsatellite instability (MSI) of the subject when the statistical measure of deviation of the plurality of quantitative measures does not satisfy the predetermined criterion. 本文公开的发明通常涉及评估受试者中的微卫星不稳定性的方法。一方面，本公开提供一种评估受试者的微卫星不稳定性的计算机实现的方法，所述方法包括：从受试者的血液样品获得多个微卫星重复元件的量化量度；处理所述多个量化