Chiral dihydropyran ring derivative as well as preparation method and application thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a chiral dihydropyran ring derivative and a preparation method and application thereof. The chiral dihydropyran ring derivative has the structure shown in the formula (I), the derivative is novel in structure, has a good anti-tumor effect, has a good inhibition effect on human osteosarcoma cells, human colon cancer cells and human non-small cell lung cancer cells, and especially has an excellent inhibition effect on the human non-small cell lung cancer cells. The inhibition IC50 of the derivative can be as low as 7 [mu]M. The derivative has a great application value in the anti-tumor effect aspect, and is expected to be prepared into anti-tumor drugs or drugs for inhibiting tumor cell proliferation, especially drugs for resisting human osteosarcoma, human colon cancer and human non-small cell lung cancer. Meanwhile, the preparation method disclosed by the invention has the advantages of cheap and easily available