ANTI-ANGIOGENESIS FUSION PROTEIN AND USES THEREOF

The present invention provides a bi-functional fusion protein, (AT)a-Fc-(VT)b, simultaneously targeting vascular endothelial growth factor (VEGF) and angiopoietins (ANGs), wherein AT is an ANG binding motif; and VT is a VEGF binding motif, Fc is an N-terminal of IgG; each of a and b is an integer from 1 to 10. The bi-functional fusion proteins contain two or more domains of human proteins and are of all human sequences, and thus are expected to be non-immunogenic, and potentially can be used therapeutically in human targeting angiogenesis-associated diseases. 本发明提供一种双功能融合蛋白，其为同时靶向血管内皮生长因子(VEGF)及血管生成素(ANG)的(AT)a-Fc-(VT)b，其中AT是ANG结合模体；VT是VEGF结合模体；Fc是IgG的N端；a及b的每一者是1至10的整数。该双功能融合蛋白含有两种或多种人类蛋白且全部为人类序列的结构域，因此预期其为非免疫原性的，并且可能用于治疗人类靶向血管新生相关疾病。