Application of pregnant woman exosome LTF protein in preparation of fetal congenital heart disease detection product, kit and detection method

The invention provides an application of a pregnant woman exosome LTF protein in preparation of a fetal congenital heart disease detection product, a kit and a detection method, and further proves that the expression of the exosome LTF protein in a maternal serum exosome with fetal ventricular septal defect is reduced. When the protein is used for detecting the fetal ventricular septal defect, early detection can be quickly and effectively achieved, and a therapeutic target and an important basis are provided for clinical application such as gene therapy, drug therapy and prevention. 本发明提供了一种孕妇外泌体LTF蛋白在制备胎儿先心病检测产品中的应用、试剂盒及检测方法，并进一步证实该外泌体LTF蛋白在胎儿室间隔缺损的母体血清外泌体中表达下调。利用该蛋白检测胎儿室间隔缺损不仅能够快速有效的做到早期检测，而且为基因治疗、药物治疗和预防等临床应用提供了治疗靶点和重要依据。