Green preparation method of (E)-alpha-cyano-beta-aryl acrylamide compound

The invention belongs to the technical field of chemical synthesis, and relates to a green preparation method of an (E)-alpha-cyano-beta-aryl acrylamide compound, in particular to a green preparation method of (E)-alpha-cyano-beta-aryl acrylamide compound based on a metalloporphyrin-enzyme continuous catalysis method. According to the method disclosed by the invention, aromatic aldehyde and malononitrile are taken as substrates, porphyrin or metalloporphyrin is taken as a catalyst, a Knoevenagel reaction is carried out under a solvent-free condition, the generated aryl methylene malononitrile compound is used for a hydration reaction under the catalysis of nitrile hydratase, and the (E)-alpha-cyano-beta-aryl acrylamide compound can be selectively generated. According to the present invention, the nitrile hydratase is adopted to perform biotransformation on the aryl methylene malononitrile compound, such that the (E)-alpha-cyano-beta-aryl acrylamide compound with high cis-trans selectivity can be synthesized,