Method for synthesizing 5-nitro-2-(propylthio) pyrimidine-4, 6-diol through continuous nitration

The invention discloses a method for synthesizing 5-nitro-2-(propyl thio) pyrimidine-4, 6-diol through continuous nitration. The synthesis method comprises the following steps: in a continuous flow reactor, taking nitrogen dioxide as a main nitrating agent, ozone as an auxiliary nitrating agent and 4, 6-dihydroxy-2-(propylthio) pyrimidine hydrochloride as a main raw material, carrying out nitration reaction to prepare the 5-nitro-2-(propylthio) pyrimidine-4, 6-diol compound. The method is extremely low in EHS risk, simple and convenient to operate, environment-friendly, high in production efficiency, high in yield, high in purity and suitable for industrial production. 本发明公开了一种连续硝化合成5-硝基-2-(丙基硫代)嘧啶-4,6-二醇的方法。该合成方法为：在连续流反应器中，以二氧化氮为主硝化剂，臭氧为辅助硝化剂，4,6-二羟基-2-(丙基硫基)嘧啶盐酸盐为主原料，经硝化反应制备5-硝基-2-(丙基硫代)嘧啶-4,6-二醇化合物。该方法EHS风险极低、操作简便、环境友好、生产效率高、收率高，纯度高，适合于工业化生产。