Mesalazine sustained-release preparation with high drug loading and preparation method thereof

The invention relates to a mesalazine sustained-release preparation and a preparation method thereof, in particular to a mesalazine sustained-release preparation with high drug loading and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The invention provides a mesalazine sustained-release pellet preparation with high drug loading capacity and a preparation method. The mesalazine sustained-release pellet comprises a blank pellet core, a drug applying layer and a sustained-release layer, and the drug applying layer contains mesalazine or a pharmaceutically acceptable salt thereof and an binder. The blank pellet core is coated with the drug applying layer and the sustained-release layer through a fluidized bed bottom spraying coating machine. The mesalazine sustained-release pellet has advantages of good roundness, good friability, high drug loading, simple and convenient preparation process, stable loading and the like. 本发明涉及一种美沙拉秦缓释制剂及其制备方法，具体涉及一种高载药量的美沙拉秦缓释制剂及其制备方法，属于药物