2'-HALOGENATED-4'-THIO-2'-DEOXY-5-AZACYTIDINE ANALOGS AND USE THEREOF

Halogenated analogs of 5-aza-2'-deoxycytidine, such as halogenated analogs of 5-aza-4'-thio-2'-deoxycytidine (5-aza-T-dCyd) are described. Pharmaceutical compositions including a halogenated analog and methods of using the halogenated analogs to inhibit neoplasia are described. In some examples, the halogenated analogs have a structure according to formula Ia, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof:. 本发明描述了5-氮杂-2'-脱氧胞苷的卤代类似物，如5-氮杂-4'-硫代-2'-脱氧胞苷(5-氮杂-T-dCyd)的卤代类似物。本发明还描述了包含卤代类似物的药物组合物以及使用卤代类似物抑制瘤形成的方法。在一些示例中，卤代类似物具有式Ia的结构，或其立体异构体、互变异构体或药学上可接受的盐。