Magnetic nano-drug carrier as well as preparation method and application thereof

The invention relates to the technical field of drug carriers, in particular to a magnetic nano-drug carrier as well as a preparation method and an application thereof. The magnetic nano-drug carrier comprises an SP94 targeting peptide and a coupling product of an siRNA delivery carrier, and the coupling product of the siRNA delivery carrier comprises superparamagnetic iron oxide nanoparticles and quaternary ammonium cationized amylose-tetraphenylethylene-superparamagnetic iron oxide nanoparticles formed by coupling quaternary ammonium cationized amylose and tetraphenylethylene, and the siRNA is adsorbed in the magnetic nano-drug carrier. The cytotoxicity experiments prove that the nano-drug carrier has good biocompatibility, good stability, targeting property and drug release property, and the magnetic nano-drug carrier can be applied to preparation of cancer gene therapy drugs. 本发明涉及药物载体技术领域，尤其是涉及一种磁性纳米药物载体及其制备方法和应用。所述磁性纳米药物载体包括SP94靶向肽和siRNA输送载体的偶联产物，所述siRNA输送载体的偶联产物包括超顺磁性氧化铁纳米颗粒、季铵阳离子化直链淀粉和四苯基乙烯偶联形成的季铵阳离子化