Preparation method of temperature-controlled double-drug preparation and application thereof in tumor postoperative treatment

The invention discloses a preparation method of a temperature-controlled double-drug preparation and application of the temperature-controlled double-drug preparation in tumor postoperative treatment. The preparation method comprises the following steps: preparing 1-methyl tryptophan protected by Bo...

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Bibliographische Detailangaben
Hauptverfasser: XU YUNRUO, WANG LIN, LIU JIA, FAN HUILING, WANG ZHENG, LI QILIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of a temperature-controlled double-drug preparation and application of the temperature-controlled double-drug preparation in tumor postoperative treatment. The preparation method comprises the following steps: preparing 1-methyl tryptophan protected by Boc, then grafting the 1-methyl tryptophan to gelatin, then removing Boc protection in an acidic solution, re-dispersing the obtained solid product in a gelatin aqueous solution to prepare a gelatin solution of modified 1-methyl tryptophan; dispersing a non-steroidal anti-inflammatory drug into the gelatin aqueous solution to prepare a gelatin solution containing the non-steroidal anti-inflammatory drug; and blending the obtained gelatin solutions respectively containing the two drugs to obtain a gelatin mixed solution loaded with the 1-methyl tryptophan and the non-steroidal anti-inflammatory drug at the same time, adding a cross-linking agent to prepare a double-drug preparation precursor solution, and finally plac