Preparation method and application of lipopolysaccharide composite nanoparticles

The invention discloses a preparation method and an application of lipopolysaccharide composite nanoparticles, and belongs to the technical field of biomedicine. The lipopolysaccharide composite nanoparticle has a stable outer membrane, the outer membrane is prepared from a polylactic acid-glycolic acid copolymer (PLGA), and a mixed aqueous solution composed of liquid fluorocarbon (PFP), indocyanine green (ICG), lipopolysaccharide (LPS) and water is encapsulated in the nanoparticle; in the composite nanoparticles, the loading capacity of ICG is 10.61% +/-0.12%, and the loading capacity of lipopolysaccharide is 1.70%. According to the lipopolysaccharide composite nanoparticles disclosed by the invention, on the basis of PLGA nanoparticles, immunologic adjuvants including LPS, ICG, oxygen and an oxygen-carrying phase change material PFP are added; therefore, the stability and half-life period of the ICG in the circulation process are improved, the ICG can be combined with photoacoustic power to induce the immun