Method for preparing 2-[(3R)-3-methylmorpholin-4-yl]-4-[1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine

Method for preparing 2-[(3R)-3-methylmorpholin-4-yl]-4-[1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine

The present invention covers a method for preparing 2-[(3R)-3- methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5- yl)-1,7-naphthyridine ("the compound of formula (I)" in the following) as well as intermediate compounds useful in the preparation of the compound of formula (...

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Bibliographische Detailangaben
Hauptverfasser: GIELING REINERUS G, VAN DER HAAS HENRICUS S, HOOGEVEEN SONJA E, PLATZEK JOHANNES, RUBENBAUER PHILIPP, DEKKER JEROEN A, VAN OERS MATTHIJS C M
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention covers a method for preparing 2-[(3R)-3- methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5- yl)-1,7-naphthyridine ("the compound of formula (I)" in the following) as well as intermediate compounds useful in the preparation of the compound of formula (I). The present invention also covers polymorphic form B of the compound of formula (I) with very high purity. 本发明涉及制备2-[(3R)-3-甲基吗啉-4-基]-4-(1-甲基-1H-吡唑-5-基)-8-(1H-吡唑-5-基)-1,7-二氮杂萘(下面的"式(I)"化合物)以及制备用于式(I)化合物的制备的中间体化合物的方法。本发明还涉及非常高纯度的式(I)化合物的多晶形式B。