Immune modifying particles for treatment of cancer

The present disclosure provides methods of treating cancer and proliferative diseases using immune-modifying particles in combination with cancer therapeutics, such as checkpoint inhibitors or biologic agents, to modify the activity of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), neutrophils, monocytes, and/or tumor-associated stroma associated with promoting tumor growth and metastasis. 本公开提供了使用免疫修饰粒子与诸如检查点抑制剂或生物剂等癌症治疗剂的组合来改变与促进肿瘤生长和转移相关的髓源性抑制细胞(MDSC)、肿瘤相关巨噬细胞(TAM)、嗜中性粒细胞、单核细胞和/或肿瘤相关基质的活性从而治疗癌症和增生性疾病的方法。