Fluorescent/MRI dual-mode probe and preparation method and application thereof

The invention discloses a fluorescent/MRI dual-mode probe as well as a preparation method and application thereof. The preparation method comprises the following step: in a protective atmosphere, carrying out reversible addition-fragmentation chain transfer polymerization reaction on a first mixed reaction system containing a fluorescent substance olefin, a gadolinium ion complex containing alkenyl, a cross-linking agent, a chain transfer agent, an initiator and a first solvent to obtain the fluorescent/MRI dual-mode probe. The fluorescent/MRI dual-mode probe is formed by polymerizing a contrast unit and a fluorescent small molecule, and the probe can perform fluorescent imaging and magnetic resonance imaging at the same time and can trace in cells for a long time; and meanwhile, the preparation method is simple and easy to operate, and raw materials are cheap and easy to obtain. 本发明公开了一种荧光/MRI双模探针及其制备方法与应用。所述制备方法包括：在保护性气氛下，使包含所述荧光物质烯烃、含烯基的钆离子络合物、交联剂、链转移剂、引发剂和第一溶剂的第一混合反应体系发生可逆加成-断裂链转移聚合反应，获得荧光/MRI双模探针。本发明通过将造